Depakote Sprinkle® capsules: Swallow whole or sprinkle on to food stuff, which include applesauce or pudding and take in instantly. Usually do not chew the sprinkle capsule or contents.
extreme multiorgan reactions. Treatment method with DEPAKOTE may perhaps cause critical multiorgan reactions that can be life-threatening or might bring about Loss of life.
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are getting it to prevent migraine complications and they are either Expecting or may turn into Expecting as you are not using efficient delivery Regulate (contraception).
The good thing about gastric lavage or emesis will vary With all the time considering the fact that ingestion. General supportive measures needs to be utilized with distinct interest to the upkeep of sufficient urinary output. Naloxone has been described to reverse the CNS depressant effects of valproate overdosage. For the reason that naloxone could theoretically also reverse the antiepileptic results of valproate, it ought to be utilized with warning in patients with epilepsy.
Depakote ER tablets and Depakote delayed-release tablets are also made use of to forestall migraine complications. Depakote ER tablets may also be made use of to deal with acute manic or mixed episodes related to bipolar ailment with or devoid of psychotic characteristics.
Overdosage with valproate could bring about somnolence, heart block, deep coma, and hypernatremia. Fatalities are reported; even so patients have recovered from valproate amounts as superior as 2,one hundred twenty mcg/mL. In overdose predicaments, the portion of drug not bound to protein is substantial and hemodialysis or tandem hemodialysis moreover hemoperfusion could end in sizeable removal of drug.
Table 4 lists therapy-emergent adverse reactions which have been noted by ≥ 5% of people from the substantial dose valproate team, and for which the incidence was increased than in the very low dose group, in the managed trial of Depakote monotherapy procedure of sophisticated partial seizures.
Table 2 summarizes All those adverse reactions claimed for individuals in these trials exactly where the incidence charge while in the Depakote-dealt with team was bigger than five% and greater compared to placebo incidence, or the place the incidence while in the Depakote-taken care of team was statistically drastically larger when compared to the placebo team.
Get in touch with your healthcare company amongst visits as required, particularly when you will be worried about signs and symptoms.
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Other birth defects that have an impact on the structures of the center, head, arms, legs, and the opening the place the urine will come out (urethra) on the bottom with the penis can also come about. Diminished hearing or hearing reduction may take place. Start defects may take place even in little ones born to women read more who're not getting any medicines and would not have other risk aspects.
Concomitant antiepilepsy drug (AED) dosage can ordinarily be decreased by close to 25% each individual 2 months. This reduction may be commenced at initiation of Depakote therapy, or delayed by one to 2 months when there is a concern that seizures are more likely to occur with a reduction. The velocity and duration of withdrawal on the concomitant AED can be very variable, and people ought to be monitored carefully during this period for greater seizure frequency.
are pregnant or may perhaps come to be Expecting. DEPAKOTE may possibly damage your unborn child. See “2. Depakote may hurt your unborn newborn” previously mentioned To find out more.